Oral Drug Development that’s Easy to Swallow

The O.G. of Pii’s drug product solutions, oral dose formulation and manufacturing is where it all began 30 years ago. Whether your finished drug format is a tablet, capsule, granules, or oral liquid, we’ve mastered it time and time again.

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In Silico Modeling

Reduce benchwork with cutting-edge multi-variate regression modeling.

Formulation Development

Consider your solubility, bioavailability, and stability problems solved.

Process Development

Processes designed to scale with your drug product.

Clinical and Commercial Manufacturing

Flexible batch sizes for clinical and commercial supply.

Softgel Capsules

Easy-to-swallow soft gels are the gold standard for patient centricity and adherence.

Oral Solid Dose

Tablets, capsules, and granules formulated for enhanced bioavailability—our bread and butter.

Oral Liquids & Suspensions

Perfect for pediatric and geriatric patients, oral liquids and suspensions are made with safety and efficacy.

Highly Potent API (HPAPI)

Nothing’s too hot for us to handle – cytotoxic, hormones, DEA-controlled substances.

Featured Resources

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Ebook

A Complete Guide to Oral Dose Manufacturing

Everything you need to know about downstream oral drug product manufacturing for capsules, tablets, liquids, and soft gels.

eBook

A Guide to Bioavailability Enhancement

Improving bioavailability and efficacy in pharmaceutics.

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Related Services

Formulation Development Services

Aseptic Drug Manufacturing

Oral Drug Manufacturing

Frequently asked questions

What types of potent materials and controlled substances can Pii handle?

Pii is equipped for high potent materials up to band 4. Each compound is individually evaluated through a rigorous EH&S program. We offer drug product solutions for DEA-controlled substances schedule I-V.

What solutions does Pii offer to address bioavailability issues?

Techniques to enhance solubility and improve bioavailability include:

Solubilization with GRAS solvents for the desired drug load
Lipid-based systems/Self-micro emulsifying drug delivery system (SMEDDS)
Spray Dried dispersion
Nanosuspension
Inclusion Complexes

What programmed drug release techniques can Pii support?

Our programmed drug-release techniques:
Immediate release
Orally disintegrating tablets
Delayed and Enteric Release

We’re all about precision when it comes to drug delivery—getting the right amount of medication to the exact absorption site, just when it’s needed. By minimizing side effects and maximizing therapeutic impact, we help improve patient outcomes every step of the way.

Here’s how our advanced release technologies make it happen:

Immediate Release
Orally Disintegrating Tablets
Delayed and Enteric Release
Targeted Release
Extended Release
Zero-Order Controlled Release

Whether it’s a fast-acting formula or a slow, steady release, our innovative solutions are tailored to meet your unique needs and deliver results with confidence

What drug product format options are there for downstream manufacturing?

At Pii, we combine cutting-edge solubility, bioavailability, and drug-release technologies with seamless scale-up and tech transfer capabilities.

Our downstream manufacturing options include:

Tablets: Bi-layer, tablet-in-tablet, mini-tablets
Capsules: Hard shell, liquid-filled hard shell (LFHS), soft gel
Solutions, Suspensions, Powders for Reconstitution
Coating: Tablets, capsules, powders, pellets